Full Version: Total corona virus worldwide 225,610,775 Cases and 4,651,757 died 14/09/21
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and here she is!!!


most cases outside wuhan! 70 procent outside that region.

Coronavirus virions are spherical with diameters of approximately 125 nm as depicted in recent studies by cryo-electron tomography and cryo-electron microscopy [2, 3]. The most prominent feature of coronaviruses is the club-shaped spike projections emanating from the surface of the virion. These spikes are a defining feature of the virion and give them the appearance of a solar corona, prompting the name, coronaviruses. Within the envelope of the virion is the nucleocapsid. Coronaviruses have helically symmetrical nucleocapsids, which is uncommon among positive-sense RNA viruses, but far more common for negative-sense RNA viruses.

Coronavirus particles contain four main structural proteins. These are the spike (S), membrane (M), envelope (E), and nucleocapsid (N) proteins, all of which are encoded within the 3′ end of the viral genome. The S protein (~150 kDa), utilizes an N-terminal signal sequence to gain access to the ER, and is heavily N-linked glycosylated. Homotrimers of the virus encoded S protein make up the distinctive spike structure on the surface of the virus [4, 5]. The trimeric S glycoprotein is a class I fusion protein [6] and mediates attachment to the host receptor [7]. In most, coronaviruses, S is cleaved by a host cell furin-like protease into two separate polypeptides noted S1 and S2 [8, 9]. S1 makes up the large receptor-binding domain of the S protein, while S2 forms the stalk of the spike molecule [10].

The M protein is the most abundant structural protein in the virion. It is a small (~25–30 kDa) protein with three transmembrane domains [11] and is thought to give the virion its shape. It has a small N-terminal glycosylated ectodomain and a much larger C-terminal endodomain that extends 6–8 nm into the viral particle [12]. Despite being co-translationally inserted in the ER membrane, most M proteins do not contain a signal sequence. Recent studies suggest the M protein exists as a dimer in the virion, and may adopt two different conformations, allowing it to promote membrane curvature as well as to bind to the nucleocapsid [13].

The E protein (~8–12 kDa) is found in small quantities within the virion. The coronavirus E proteins are highly divergent but have a common architecture [14]. The membrane topology of E protein is not completely resolved but most data suggest that it is a transmembrane protein. The E protein has an N-terminal ectodomain and a C-terminal endodomain and has ion channel activity. As opposed to other structural proteins, recombinant viruses lacking the E protein are not always lethal, although this is virus type dependent [15]. The E protein facilitates assembly and release of the virus (see Subheading 4.4), but also has other functions. For instance, the ion channel activity in SARS-CoV E protein is not required for viral replication but is required for pathogenesis [16].

The N protein constitutes the only protein present in the nucleocapsid. It is composed of two separate domains, an N-terminal domain (NTD) and a C-terminal domain (CTD), both capable of binding RNA in vitro, but each domain uses different mechanisms to bind RNA. It has been suggested that optimal RNA binding requires contributions from both domains [17, 18]. N protein is also heavily phosphorylated [19], and phosphorylation has been suggested to trigger a structural change enhancing the affinity for viral versus nonviral RNA. N protein binds the viral genome in a beads-on-a-string type conformation. Two specific RNA substrates have been identified for N protein; the TRSs [20] and the genomic packaging signal [21]. The genomic packaging signal has been found to bind specifically to the second, or C-terminal RNA binding domain [22]. N protein also binds nsp3 [18, 23], a key component of the replicase complex, and the M protein [24]. These protein interactions likely help tether the viral genome to the replicase–transcriptase complex (RTC), and subsequently package the encapsidated genome into viral particles.

A fifth structural protein, the hemagglutinin-esterase (HE), is present in a subset of β-coronaviruses. The protein acts as a hemagglutinin, binds sialic acids on surface glycoproteins, and contains acetyl-esterase activity [25]. These activities are thought to enhance S protein-mediated cell entry and virus spread through the mucosa [26]. Interestingly, HE enhances murine hepatitis virus (MHV) neurovirulence [27]; however, it is selected against in tissue culture for unknown reasons [28].

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Coronavirus Life Cycle
Attachment and Entry

The initial attachment of the virion to the host cell is initiated by interactions between the S protein and its receptor. The sites of receptor binding domains (RBD) within the S1 region of a coronavirus S protein vary depending on the virus, with some having the RBD at the N-terminus of S1 (MHV), while others (SARS-CoV) have the RBD at the C-terminus of S1 [29, 30]. The S-protein–receptor interaction is the primary determinant for a coronavirus to infect a host species and also governs the tissue tropism of the virus. Many coronaviruses utilize peptidases as their cellular receptor. It is unclear why peptidases are used, as entry occurs even in the absence of the enzymatic domain of these proteins. Many α-coronaviruses utilize aminopeptidase N (APN) as their receptor, SARS-CoV and HCoV-NL63 use angiotensin-converting enzyme 2 (ACE2) as their receptor, MHV enters through CEACAM1, and the recently identified MERS-CoV binds to dipeptidyl-peptidase 4 (DPP4) to gain entry into human cells (see Table ​Table11 for a list of known CoV receptors).
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Is this the full china update???
Uhm yes !

So I get my china meal now ....
Huge spike !!
MAINLAND CHINA Cases Deaths Notes Links
Hubei province
(including Wuhan) 5,806 204 804 serious, 290 critical Source
Zhejiang province 428 0 54 serious Source
Guangdong province 354 0 37 serious, 13 critical Source
Henan province 278 2 37 serious, 4 critical Source
Hunan province 277 0 38 serious Source
Anhui province 200 0 Source
Chongqing 182 0 18 serious, 4 critical Source
Jiangxi province 162 0 16 serious Source
Shandong province 158 0 Source
Sichuan province 142 1 2 critical Source
Jiangsu province 129 0 1 serious Source
Beijing 121 1 14 serious, 2 critical Source
Shanghai 112 1 4 critical Source
Fujian province 101 0 12 serious, 3 critical Source
Guangxi Region 78 0 5 serious, 2 critical Source
Yunnan province 76 0 6 serious, 2 critical Source
Hebei province 65 1 8 serious Source
Shaanxi province 63 0 1+ serious Source
Hainan province 46 1 7 serious Source
Heilongjiang province 44 2 7 serious Source
Liaoning province 41 0 9 serious Source
Shanxi province 35 0 3 serious, 2 critical Source
Tianjin 31 0 13 serious Source
Gansu province 29 0 5 serious, 1 critical Source
Inner Mongolia 18 0 2 serious, 2 critical Source
Ningxia Region 17 0 Source
Jilin province 14 0 1 serious Source
Xinjiang 14 0 3 serious, 1 critical Source
Guizhou province 12 0 3 serious Source
Qinghai province 8 0 1 serious, 7 stable Source
Tibet 1 0 Source
TOTAL 9,042 213 1,370 serious
124 recovered
12,167 suspected
REGIONS Cases Deaths Notes Links
Hong Kong 12 0 Source
Taiwan 9 0 All stable Source
Macau 7 0 Source
TOTAL 28 0 0 serious
INTERNATIONAL Cases Deaths Notes Links
Thailand 14 0 Source
Japan 14* 0 Source
Singapore 13 0 All stable Source
Malaysia 8 0 Stable Source
Australia 9 0 Stable Source
France 6 0 2 serious Source
United States 6 0 Source
Germany 5 0 Source
South Korea 6 0 Source
UAE 4 0 Stable Source
Canada 3 0 Source
Vietnam 5 0 1 recovered Source
Nepal 1 0 Source
Cambodia 1 0 Source
Sri Lanka 1 0 Source
Finland 1 0 Source
Philippines 1 0 Source
India 1 0 Stable Source
Italy 2 0 Source
TOTAL 101 0 2 serious
4 more cases!
Shanxi region 4 more cases!
Such a mess let us pray. heartflowers
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