Experimental mRNA-LNP vaccine elicits robust immune response in calves, offering new hope for containing the U.S. HPAI outbreak.
The recent spread of highly pathogenic avian influenza (HPAI) H5N1 clade 2.3.4.4b into U.S. dairy cattle herds has raised alarms among public health experts, veterinarians, and global health authorities. In a new preprint study, researchers from institutions funded by the National Institutes of Health, USDA, and U.S. Department of Energy have demonstrated that an experimental mRNA-lipid nanoparticle (mRNA-LNP) vaccine targeting the H5 HA protein induces strong immune responses in Holstein calves.
This study provides timely and potentially transformative insights into a potential intervention strategy. The vaccine, adapted from the same platform used in human COVID-19 mRNA vaccines, may help reduce viral spread among cattle and limit the risk of zoonotic transmission.
Cutting-Edge mRNA Vaccine Shows Promise Against H5N1 in Dairy Cattle
— NABC/K-State (@KSU_NABC) May 9, 2025
Experimental mRNA-LNP vaccine elicits robust immune response in calves, offering new hope for containing the U.S. HPAI outbreak.https://t.co/LQdzvP45Gb
